At 50% V o 2max for 30 and 60 min, 50 and 75% reductions of the premeal insulin dose were associated with plasma glucose of −0.39 and +0.49 mmol/l, respectively, at the end of the exercise. At 25% V o 2max for 60 min, a 50% reduction in the premeal insulin dose resulted in plasma glucose of −0.62 mmol/l compared with baseline at the end of exercise.
RESULTS-At all intensities, the full premeal insulin dose was associated with an increased risk of hypoglycemia.
Each subject served as his own control and was tested after a full dose of insulin LP (LP 100%) and/or 50% (LP 50%) and/or 25% (LP 25%) of the current dose. RESEARCH DESIGN AND METHODS-Eight male type 1 diabetic patients on a basal-bolus insulin regimen of ultralente (UL) as basal insulin and lispro (LP) as premeal insulin were tested in a randomized, crossover fashion during postprandial exercise at 25% V o 2max for 60 min, 50% V o 2max for 30 and 60 min, and 75% V o 2max for 30 min starting 90 min after a standardized mixed breakfast (600 kcal, 75 g carbohydrates).
OBJECTIVE-To evaluate and validate appropriate premeal insulin dose reductions for postprandial exercises of different intensities and durations to minimize the risk of exercise-induced hypoglycemia in type 1 diabetic subjects.